The most common cannabinoids THC and CBD are probably familiar to almost every grower and marijuana enthusiast. But the cannabichromene, also known as CBD, is probably something few people have heard of. It is considered one of the six most medically researched cannabinoids. Although it has not become as popular as THC and CBD, due to its less pronounced effects on the human body, its medicinal qualities are still extremely promising for modern medicine. But first, let us try to understand what this cannabinoid is and how it interacts with the human body as well as what is ohio medical card.
CBD synthesis in cannabis
CBDH was discovered over 50 years ago. Its biosynthesis by cannabis follows the same principle as THC and CBD. The precursor of all these plant cannabinoids is cannabigerolic acid (CBDH). It is formed by combining geranylpyrophosphates with olive acid within the plant. It is then converted to cannabichromene, cannabidiol and delta-9-tetrahydrocannabinolic acids by independent cyclase class enzymes. This is then broken down into simpler substances.
Under the influence of heat and ultraviolet radiation, the acids are converted into free cannabinoids that can affect the human body. One of these is CBC. It is considered one of the three main ones because it is genetically determined how the plant synthesizes it. All other cannabinoids are decay products of these three.
Interactions of CBC with brain receptors and other cannabinoids
CBC has no psychoactive effects on the body, so it is not possible to feel its effects. The reason for this is that it does not interact well with the CB1 cannabinoid receptors that are found in the human brain. However, this cannabinoid is able to bind to other types of receptors, which include vanilloid (TRPV1) and transient (TRPA1). It is these that are directly related to the body’s ability to feel pain. Once CBC activates these receptors, a large amount of natural endocannabinoids are released, which are capable of relieving pain sensation.
As for interactions with other cannabinoids, CBC is able to enhance the cerebral effects of THC. It helps it to activate the pleasure receptors faster, which leads to a more rapid mood elevation. A euphoric effect occurs. Scientists have found that the highest concentrations of CBD are found in the sativa varieties of marijuana. This is most likely why they are known for their uplifting effect, which in grower circles is commonly referred to as the “high” effect.
The healing properties of CBD
The positive qualities of CBCs identified by scientists could, in the future, contribute to the creation of more effective therapeutic agents with no, or minimal, side effects. The greatest prospects are seen in several areas of medicine. These will be discussed below.
The fact that CBC is a potential cancer fighter first became known in 2006 when a research report on the effects of cannabinoids on cancer cells was published. CBC was found to be the second most important substance found in cannabis to be effective against cancer development. Compared to THC, which was already a known anti-cancer drug at the time, CBD had an undeniable advantage. It did not have the potent psychotropic effects that make THC difficult to use in treatment. Recent studies conducted on mice induced tumors have shown that CBC is indeed effective in countering inflammation and inhibiting tumor growth.All this gives hope that scientists will soon be able to use CBC and other cannabinoids in the fight against cancer, greatly increasing the effectiveness of their treatments.
Pain and Inflammation
It is well known that cannabichromene can block the pain and inflammation caused by a condition common in old age, such as osteoarthritis. It works quite differently from nonsteroidal anti-inflammatory drugs, and it also does not cause the side effects of these drugs.
A recent animal study revealed another interesting nuance. It turns out that when THC and CBC are used simultaneously, their combined effect has a much greater effect on inflammation than when these cannabinoids are used separately.
In 2013, there was a study that looked at the effects of CBC on brain cells. It was found to have a positive effect on neural stem cells, which are essential for healthy brain function. In the presence of CBCs, they become more viable and this, in turn, has a positive effect on the synthesis of astrocytes, which play the most important role in maintaining brain homeostasis.
Astrocytes are responsible for a number of important functions, including controlling neurotransmitters and protecting cells from oxidative stress. They are also effective in resisting inflammation and reducing toxicity. And it is the disruption of all of these functions that leads to brain diseases, particularly Alzheimer’s disease.
One research group that studied the positive effects of CBD on acne also conducted similar studies with CBD. This cannabinoid was found to be a potent inhibitor of this disease. It is known to result from excessive sebum production and inflammation of the sebaceous glands. CBC was found to exhibit strong anti-inflammatory properties, as well as suppressing excessive lipid production in the sebaceous glands. It also reduces levels of arachidonic acid, which is essential for converting simple sugars to fatty acids. Undoubtedly, there is still a lot of research to be done, but one day CBC may end up as part of a very strong anti-acne treatment.
When combined with THC and CBDH, CBDH has been found to help in the process of delivering natural antidepressants to the brain. This suggests that marijuana and its derivatives can relieve a person of lingering depression by bringing joy into their lives. The development of drugs based on these three cannabinoids has not yet begun. However, everyone knows that marijuana has long been used to treat depression in countries where it is legal.
Undoubtedly, the therapeutic properties of CBD have not yet been sufficiently studied for official medicine to be finally convinced not only of its efficacy, but also of its safety. It will take a long time to create new drugs based on them. The illegal status of cannabis is a major impediment, but this barrier has been overcome in many countries. So we can be sure that new and more effective medicines will soon be available to everyone.